摘要
von Willebrand factor (vWF) is an important compound in the human plasma. which is synthesized by endotlrelial cells and also by megakaryocytes. The gene for vWF is located near the tip of the short arm of chromosome 12, being approximately 180 kb in length and consisting of 52 exons separated by 51 introns. The mature vWF subunit consists of 2 050 amino acid residues with molecular weight of about 250 ku. In plasma vWF appears as various multimers. vWF has two well-characterized functions.
von Willebrand factor （vWF） is an important compound in the human plasma, which is synthesized by endotlrelial cells and also by megakaryocytes. The gene for vWF is located near the tip of the short arm of chromosome 12, being approximately 180 kb in length and consisting of 52 exons separated by 51 introns. The mature vWF subunit consists of 2 050 amino acid residues with molecular weight of about 250 ku.
出处
《血栓与止血学》
2005年第4期147-149,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
血液疾病
巨核细胞
染色体
致病因素
出血性疾病
von Willebrand factor
von Willebrand factor -cleaving protease
von Willebrand disease
