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骨髓间质干细胞体外分化为胰岛细胞的研究进展 被引量：4

Research advancement of the stem cells of the bone marrow interstitial substance differentiating into islet cells
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摘要 Type I diabetes mellitus （T1DM） is a chronic metabolic disease liable to teenagers all over the world. Its mechanism is due to the attack of auto-immune system on the body’s own islet cells leading to hyperglycemia with great damages to the body. The implantation of islet cells is an effective way of curing T1DM. The authors reviewed in detail the research advancement of islet cell source from stem cells of the bone marrow interstitial substance. Type I diabetes mellitus （T1 DM） is a chronic metabolic disease liable to teenagers all over the world. Its mechanism is due to the attack of auto-immune system on the body＇ s own islet cells leading to hyperglycemia with great damages to the body. The implantation of islet cells is an effective way of curing T1DM. The authors reviewed in detail the research advancement of islet cell source from stem cells of the bone marrow interstitial substance. （J Intervent Radiol, 2005, 14：433-435. ）
作者 李爱梅 邓钢
机构地区 东南大学附属中大医院介入放射科
出处 《介入放射学杂志》 CSCD 2005年第4期433-435,共3页 Journal of Interventional Radiology
关键词 胰岛细胞 细胞体外分化 骨髓间质 胰岛素分泌功能受损 慢性代谢性疾病 1型糖尿病 估计发病率 自身免疫系统 T1DM Type I diabetes mellitus Stem cells Islet cells Implantation
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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  • 1Colman A. Making new beta cells from stem cell. Semin Cell Dev Biol, 2004,15:337-345.
  • 2Ammon B, Ramiri PV. In vitro-generation of surrogate islets from adult stem cells . Transpl Immunol, 2004,12: 259-272.
  • 3Gordon CW. Can we make surrogate β-cells better than the original?.Semin Cell Dev Biol, 2004,15:347-357.
  • 4Street CN, Sipione S, Helms L, et al. Stem cell-based approaches to solving the problem of tissue supply for islet-transplantation in type 1 diabetes. Int J Biochem Cell Biol, 2004, 36: 667-683.
  • 5Pittengre MF, Mackay AM, Beck SC, et al. Multilineage potential of adult mesenchymal stem cells. Science, 1999,284:143-147.
  • 6Kucia M, Ratajczta J, Reca R. Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury. Blood Cells, Mol Dis, 2004,32: 52-57.
  • 7Short B, Brouard N, Ramakrishnan A, et al. Mesenchymal Stem Cells. Arch Med Res, 2003, 34: 565-571.
  • 8Rouffose LA, Direkzi NC, Otto WR, et al. Circulating mesenchymal stem cells. Int J Biochem Cell Biol, 2004,36: 585-597.
  • 9Barry FP, Murphy JM. Mesenchynal stem cells: clinical application and biological characterization. Int J Biochem Cell Biol, 2004, 36:568-584.
  • 10贾延劼,周燕,杨于嘉,董为伟.干细胞诱导分化为胰岛的研究进展[J].中华内分泌代谢杂志,2004,20(1):87-89. 被引量：16

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介入放射学杂志
2005年 第4期

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