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升高高密度脂蛋白的临床意义及其药物的研究进展 被引量:7

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摘要 如何通过升高高密度脂蛋白胆固醇降低冠心病的发生,是最近许多科学家的研究热点。本文阐述了高密度脂蛋白抗氧化、抗炎、抗血栓、促纤溶、减轻内皮功能不全、抑制平滑肌细胞增殖、升高前列环素、清除毒性磷脂等功能,以及高密度脂蛋白在胆固醇逆转运中的作用,并对目前升高高密度脂蛋白的方法及药物研究进展进行了综述。
作者 查政 郭志刚
出处 《国外医学(药学分册)》 2005年第4期226-230,共5页 Foreign Medical Sciences(Section of Pharmarcy)
基金 国家自然科学基金资助项目(30171028 30471929) 广东省自然科学基金资助项目(010616)
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  • 1Brousseau ME, Bodzioch M, Schaefer EJ, et al. Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease [ J ]. Atherosclerosis, 2001, 154 (3):607-611.
  • 2Oda MN, Bielicki JK, Ho TT, et al. Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins[J]. Biochem Biophys Res commun, 2002, 290(3):921 -927.
  • 3O'Connell BJ, Genest J Jr. High-density lipoproteins and endothelial function[J]. Circulation, 2001, 104 (16):1978- 1983.
  • 4Vaisman BL, Lambert G, Amar M. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice[J]. J Clin Invest, 2001, 108(2) :303 - 309.
  • 5Nakanishi N, Nakamura K, Suzuki K, et al. Relation of body weight change to changes in atherogenic traits: a study of middle-aged Japanese obese male office workers[J]. Ind Health, 2000, 38(2):233 - 238.
  • 6Bowen PH, Guyton JR. Nonpharmacologic and pharmacologic treatment of patients with low levels of high-density lipoprotein cholesterol [J]. Curr Atheroscler Rep, 2000, 2(1):58-63.
  • 7Bossé Y, Pascot A, Dumont M, et al. Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil [ J ]. Genet Med,2002, 4(4):311-315.
  • 8Lipka LJ. Ezetimibe: a first-in-class, novel cholesterol absorption inhibitor[J]. Cardiovasc Drug Rev, 2003, 21(4) :293 - 312.
  • 9Mauro VF, Tuckerman CE. Ezetimibe for management of hypercholesterolemia[ J]. Ann Pharmacother, 2003, 37(6) :839 - 848.
  • 10Tellier P. Ezetimibe: from pharmacology to clinical trials[J]. Ann Endocrinol(Paris), 2003, 64(6):442-447.

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