摘要
目的比较后程加速超分割(LCAF)和常规分割放射治疗食管癌的疗效和毒性。方法64例食管癌患者随机分成两组,CF组(32例)1次/d,2Gy/次,5次/周,总剂量60～68Gy,30～34次,6～7周完成;LCAF组(32例)前36Gy照射常规分割完成,36Gy后缩野改加速超分割,1.5Gy/次,2次/d,照射剂量24～30Gy,总剂量60～66Gy,34～38次,5.2～5.6周完成。结果所有病例均完成疗程,两个组急性反应差异无显著意义(P>0.05)。1、3、5年生存率CF组分别为46.9%,21.9%,12.5%,LCAF组分别为53.1%,28.1%,15.6%,两个组差异无显著意义(P>0.05);1、3、5年局部控制率CF组分别为40.6%,25%,21.9%,LCAF组分别为62.5%,53.1%,43.8%,LCAF组优于CF组。结论食管癌后程加速分割放射治疗的局控率优于常规放射治疗组,生存率之间差异无显著意义,毒性反应无明显增加。
Objective To compare the result and side-effect late-course accelerated hyper fraction （LCAF） regimen and conventional fractionation （CF） regimen in the radiotherapy for esophageal carcinoma. Methods Sixty-four patients with esophageal carcinoma were randomized into two groups. The CF group received routine radiotherapy 2 Gy per day ,5 times a week to a total dose of 60～68 Gy in 6～7 weeks. The LCAF group received conventional fractions in the first part of the treatment to a dose 36Gy/18 f/3.6 w, followed by accelerated fractionated irradiation using reduced fields, twice daily at 1.5 Gy per fraction with a minimum interval of 6 hours between fractions. The dose by the accelerated technique was 24～30 Gy. So the total dose of 60～66 Gy/34～38 f/5.2～5.6 w. Results There were no significant difference in acute response between groups （P〉0.05）. The 1,3,5-year local tumor control rates of LCAF group were significantly improved when compared to CF group, being 62.5% ,53.1% ,43.8% vs 40.6% ,25% ,21.9% respectively （P〈0.05）. The 1,3,5-year surival rates were 53.1% ,28.1%, 15.6% in LCAF group and 46.9%,21.9% ,12.5% in CF group （P〉0.05）. Conclusion local control rate of late-course accelerated hyper fractionated of esophageal carcinoma is better than the conventional radiotherapy, however there is no significant difference in survival rate between two groups. It is well to lerated.
出处
《安徽医学》
2005年第5期369-371,共3页
Anhui Medical Journal
