摘要
目的查明人感染猪链球菌病感染来源和途径,流行范围,流行特征与特点,为制定预防控制措施提供依据。方法制订统一的临床诊断标准对病例进行诊断,制订统一的流行病学个案调查表进行流行病学调查,采集病例的早期血、脑脊液样和病死猪组织样进行病原分离和鉴定,收集患者的临床表现和检查结果,对死亡病例进行病理改变观察,综合以上信息进行分析。结果2005-07中旬以来,发生在四川省资阳市等地的不明原因疾病,经调查证实为猪链球菌2型引起的人感染猪链球菌病。截至2005-08-09,在四川省的12个地区共发现病原学确诊和临床诊断病例180例,疑似35例,死亡39例。病例主要分布在资阳、内江2市,感染途径为宰杀、洗切病死猪等家畜,病例散在发生,病例之间无接触史,无续发病例,无人传人的现象,病例以参与宰杀病死猪的农村男性为主。病例的临床分型主要为脑膜炎和休克型,潜伏期短,平均2.37d,病理改变主要表现为全身多器官受损,败血症伴弥漫性血管内凝血。结论2005-07中旬以来,发生在四川省资阳市等地的人感染猪链球菌病,病原菌为猪链球菌2型,感染途径为直接接触(宰杀、洗切)病死猪等家畜。病例主要表现为脑膜炎型和休克型。
Objective To investigate the transmission and prevalence level and epidemiological characteristics of human infections caused by streptococcus suis in order to provide evidence for control and prevention for this disease. Methods Consistent clinical criteria combined with epidemiological investigations were used to diagnose the clinical human cases with the infections; pathogens isolated from blood, cerebrospinal samples from early stage infective human cases and tissue samples from died and/or sick pigs were separated and identified; clinical symptom and relative testing results from human cases were analyzed; pathological examinations from died patients were observed. Results The investigation confirmed that the unknown human infections which prevailed in Ziyang city from the middle of July, 2005, was cause by serotype 2 of Streptococcus suis. Up to 9th August, 2005, 180 of human cases were clinical diagnostic and pathogen confirmed patients, 35 were suspected cases and 39 were dead cases. All those cases were distributed to 12 districts of Sichuan province, mainly in Ziyang city and NeiJiang city. Directly contact the died and/or sick pigs such as slaying, incision was the main transmission route from animals to humans. Human cases were highly scattered, no evidence of infections between humans was observed. Male patients were dominant in the total numbers of patients. Human clinical symptom were classified into two types： meningitis and shock, the average latent period was 2.37 days. Multi - organs being damaged and sapraemia combined with DIC were the main pathological changes. Conclusions The unknown huma, n infections which prevailed in Ziyang city from the middle of July,2005, was cause by serotype 2 of streptococcus suis. Directly contact the died and/or sick pigs （such as slaying, incision） was the main transmission route from animals to humans. Human clinical symptom were classified into two types： meningitis and shock.
出处
《预防医学情报杂志》
CAS
2005年第4期379-383,共5页
Journal of Preventive Medicine Information
基金
四川省疾病预防控制中心(四川成都610031)
关键词
猪链球菌病
流行病学
调查
Streptococcus suis
Epidemiological
Investigation
