摘要
目的:研究慢性心房颤动(CAF)患者血清心房利钠肽(ANP)、脑利钠肽(BNP)水平的变化及其临床意义。方法:放射免疫分析测定102例CAF患者、40例无CAF患者和30例对照组的血清ANP、BNP水平,并进行统计分析。结果:CAF组血清ANP和BNP水平均显著高于无CAF组和对照组(P均<0.01);无CAF组血清BNP显著高于对照组(P<0.01),但ANP与对照组无显著差异(P>0.05),CAF组中ANP与BNP成显著正相关(P<0.01)。CAF患者中Ⅰ、Ⅱ、Ⅲ、Ⅳ级心功能组间平均血清ANP、BNP水平依次显著性递增(P<0.01)。住院期间死亡组血清ANP和BNP水平也显著高于好转出院组(P<0.05,P<0.01)。结论:CAF患者血清ANP和BNP水平显著增高,并随心功能分级依次递增,死亡组更高。
Objective To study the clinical significance of changes of serum ANP and BNP levels in patients with CAF. Methods Serum ANP and BNP levels were determined with RIA in 102 patients with CAF, another 40 patients with cardiac diseases but without CAF and 30 controls. Results Serum levels of ANP and BNP in patients with CAF were significantly higher than in patients without CAF and controls （both P 〈0.01 ）. Serum levels of BNP in patients without CAF were significantly higher than those in controis （P 〈0.01 ） but levels of ANP were not much different from those in controls （P 〉 0.05）. The serum levels of ANP, BNP in patients with CAF increased gradually as the cardiac function deteriorated from Grade Ⅰ to Grade Ⅳ, with differences between the levels in each consecutive grades being significant （P 〈0.01 ）. As a whole, levels of ANP and BNP were mutually positively correlated （P 〈 0.01 ）. In patients who died in the hospital （n = 7） , the levels of ANP and BNP were also significantly higher than those in the patients who improved （P 〈0.05, P 〈0.01 ）. Conclusion Serum ANP and BNP levels were significantly increased in patients with CAF, with the highest levels in patients with grade IV cardiac function and those who died.
出处
《放射免疫学杂志》
CAS
2005年第4期259-260,共2页
Journal of Radioimmanology
