摘要
目的:探讨甲状腺功能亢进症的循环系统变化机制及普洛奈尔对其影响作用。方法:测定肌注L-T4及L-T4加普洛奈尔所致甲状腺功能亢进兔和对照组的心肌肌质网钙、镁-三磷酸腺苷酶活性。结果:L-T4组及L-T4加普洛奈尔组心肌肌质网钙、镁-三磷酸腺苷酶活性明显高于对照组,而且酶活性与血TT3浓度呈显性正相关,L-T4加普洛奈尔组与L-T4组的心肌肌质网钙、镁-三磷酸腺苷酶活性无明显差别。结论:甲状腺激素对心肌肌质网钙、镁-三磷酸腺苷酶活性的激活作用是不依赖于β受体的直接作用。
bjective： To investigate the effects of L-thyroxine-induced hyperthyroidism on rabbit myocardial sarcoplasmic reticulum Ca-ATPase activity （SERCA2） and the influence of propanolol on it. Methods： L-thyroxine （L-T4）, L-thyroxine Plus propranolol （L-T4 ＋ prop） and 0. 9% NaC1 （Ctr） were administered to rabbits by muscle injection and SERCA2 activity was measured. Results.. SERCA2 activity in L-T4 and L-T4 ＋ prop groups significantly higher than in control groups and there is a positive correlation between the serum TT3 concentration and SERCA2 activity. No marked difference of SERCA2 activity between L-T4 and L-T4 ＋ prop group are found. Conclusions： Thyroid hormone can stimulate the myocardial SERCA2 activity and this effect is independent of β receptor.
出处
《内科急危重症杂志》
2005年第4期164-165,170,共3页
Journal of Critical Care In Internal Medicine
