摘要
我们采用ｒＩＮＦ－γ皮下注射治疗了２７例ＡＤ患者，经过３周及４～６周治疗后病情严重度积分较治疗前明显下降（Ｐ值均＜０．００１），而对照组１３例患者皮下注射白蛋白后病情严重度积分无明显下降（Ｐ均＞０．０５）；３周后治疗组总有效率（４８％）高于对照组（１５％），但无统计学意义，４～６周后治疗组总有效率（７５％）明显高于对照组（２２％）（Ｐ＜０．０５）。ｒＩＮＦ－γ的主要副作用为：发热、乏力、肌痛或／和关节痛。
Twenty seven patients with atopic dermatitis (AD) were treated with rIFN-γ(subcutaneous injection).The average severity for scorc 25 patients was signifieatly reiluced(P<0.001)after 3 weeks rIFN-γ therapy,and more marked after 4～6 wks treatment(n=20).There was no significant improvement in the controlled group after 3 wks even after 4～6 wks human albumin injection.The response rate in the treatment group(48%)looks higher than that of controlled group(15%) after 3 wks treatment,but no statistie significant(P>0.05).While after 4～6 wks treatment,there was marked difference(75%)vs 22% respctively)and statistically with significant difference(P<0.05).The most frequent.side effects were fever,fatigue,myalgia and/or artjralgia.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
1995年第2期93-95,共3页
Journal of Clinical Dermatology
