摘要
作者对三年前曾经注射过高价人抗ＨＢｓ（Ａｂｉ）的１１名健康志愿者复查血清内的ＨＢｓＡｇ，抗独特型抗体（Ａｂ＿２）和抗－抗－独特型抗体（Ａｂｓ）水平，发现ＨＢｓＡｇ皆为阴性，Ａｂｓ水平高于Ａｂ＿２，说明在这三年期间，无人感染乙肝病毒。由于Ａｂ＿１在体内激活了免疫网络，导致Ａｂ＿２和Ａｂ＿３在体内相互调节，使机体处于稳定的免疫状态，再次证明了外源性人抗ＨＢｓ在一定条件下，不仅可引起被动免疫，还可诱导主动免疫。
In this report, the regulative effect of the human anti-HBs was studled in humanbody. 103health volunteers were injected with high titre human anti-Hbs(Ab_1) three years ago, 11 cases were followedto detect the HBsAg, anti-idiotypic anti-bodies(Ab_2 ) and anti-anti-idiotypic antibodies(Ab_3) in sera,Wefound that nobody was infected HBV during this period, and usually the titre of Ab_3 were higher than that ofAb_2. These results reconfirmed that the dynamic changes between Ab_2 and Ab_3 of immune sera were to becyclical by way of their interaction,injection of exogenous human anti-HBs not only could bring about passiveimmunity but also could induce active immunity by activation of idiotyplc network in humanbody.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1995年第4期233-234,241,共3页
Immunological Journal
基金
国家自然科学基金
