摘要
综述了蛋白质折迭的基本实验特征，讨论了量子构象动力学的有关理论结果，分析了格子模拟得到的启示，在此基础上对Ａｎｆｉｎｓｅｎ的热力学假设提出质疑，提出鲁棒极小值的概念，研究了序列决定构象（第二遗传密码）问题，并对折迭途径中的一些问题进行了初步探讨。
he experimental characteristics of protein folding are reviewed. The theoretical results ofquantum conformation dynamics and lattice simulation are discussed.Instead of Anfinsen's ther-modynamic hypothesis on protein folding we propose the concept of robust minimum. The prob-lem of the second genetic code──“if sequence ,then conformation”──is investigated.Theproblem of dependence on pathway is discussed briefly at the end of the article.
出处
《内蒙古大学学报（自然科学版）》
CAS
CSCD
1995年第2期172-180,共9页
Journal of Inner Mongolia University：Natural Science Edition
基金
国家自然科学基金
关键词
蛋白质
氨基酸序列
折迭途径
构象动力学
protein folding amino acid sequence thermodynamic stability second genetic code conformation dynnmics folding pathway
