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抑制素亚基基因在哺乳类动物卵巢的表达与调控的研究进展 被引量:2

Progress in the Study of Inhibin Subunit Gene Expression and Regulation in Mammalian Ovary
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摘要 抑制素(inhibin)是由二硫键连接的α和β两个不同亚单位所构成的糖蛋白,它具有抑制卵泡刺激素(FSH)的合成和分泌的作用。β亚单位借助二硫键尚可形成β亚单位二聚体──激活素(activin),它则具有刺激FSH分泌的作用。本文介绍了抑制素亚基cDNA的克隆及抑制素亚基基因在哺乳类卵巢表达与调控的研究进展,并指出在研究抑制素基因表达时应予注意的问题。 Inhibin is a glycoprotein hormone composed of an α-subunit and a β-subunit.It suppresses pituitary FSH secretion. Activin is a dimer of β-subunits of inhibin,which stimulates pituitary FSH secretion. This review is a survey of recent research progress in gene expression and regulation of inhibin/activin,particularly pointing out some questions in studying gene expression of inhibin.
出处 《生理科学进展》 CAS CSCD 北大核心 1995年第3期204-208,共5页 Progress in Physiological Sciences
关键词 抑制素 激活素 基因表达 哺乳动物纲 卵巢 Inhibin Activin Gene expression
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  • 1陈敏,张友南.表皮生长因子对生殖内分泌作用的研究进展[J].生理科学进展,1994,25(2):153-156. 被引量:5
  • 2杨军.内皮素促进下丘脑—垂体—卵巢激素的释放[J]生理科学进展,1992(02).
  • 3童国遐.卵巢中存在GnRH的mRNA[J]生理科学进展,1991(04).
  • 4童国遐.卵巢中存在免疫活性的促肾上腺皮质激素[J]生理科学进展,1991(04).
  • 5Burns WN,McCill JR,RoyAK,et al.Expression of the humn inhibin a-subunit geene In preovulatorygronulosa-tgeca cells. American Journal of Obstetrics and Gynecology . 1990
  • 6Maruo T,et al.Comparison of the facilitative roles of insulin and insulin—like growth factor I in thefunctional differentiation of granulose cella: in vitro stuides with porcine model. Acta Endocrinologica . 1988
  • 7DepaoloLV,Bicsak TA,Erickson GF,et al.Follistation and activin:a potential Intrinsic regulatory systemwithin diverse tissue. Proceedings of the Society for Experimental Biology and Medicine . 1991
  • 8Vorob EO,Svechnikovs FA,Nikitin AI,et al.Ovarian steroid synthesis in tissue cultur afer administrationof hormones and epldermal growth factor. Arkhiv Anatomii Gistologii i Embriologii . 1991
  • 9Xiao s,Findlay JK,Robertson DM.The effect of bovine activin and lellicle- stimulating hormong(FSH)suppessing protein/follistatin on FSH- Induced differentiation of rat granulose cells in vitro. Molecular and Cellular Endocrinology . 1990
  • 10Nakstani A,Shimasaki S,Sepaolo L V,et al.Cyclic changes in follictation messenger ribonudeic acid andits Protein In the rat ovary during the estrous cycle. The Journal of Endocrinology . 1991

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