摘要
以国产氟啶酸于北京、西安及广州等地5所医院治疗临床全部病原阳性、急性细菌性感染173例。含急性菌痢86例、伤寒12例、泌尿道感染25例、淋病40例、肺炎4例、沙门氏菌感染4例、副溶血弧菌及粘质沙雷氏菌肠炎各1例。经一疗程治疗,急性菌痢、伤寒及泌尿道感染全部显效,淋病75％显效,其余10例8例显效,2例进步,总有效率93.06％。除1例鼠伤寒、1例肺炎杆菌及10例淋球菌外,其余病原菌均经一疗程全部转阴。 ENX和NFX MIC90,痢疾杆菌、伤寒杆菌及大肠杆菌均≤0.2μg/ml。毒副反应发生率为4.62％,均未影响疗程完成。
173 cases with acute bacterial infection were treated with Chinese made Enoxacin in five different hospitals in Beijing, Xian and Guangzhou. All patients had positive bacterial cultures. There were 86 cases of bacilliary dysentry,12 of typhoid fever, 25 of urinary tract infection. The therapeutic effects were excellent for these patients, while 30 out of 40 cases of gonorrhea were cured through one course of treatment. Another 10 cases were 4 of pneumonia and 4 of salmonellosis,one of parahemolytic vibro and one of maxcesons serratia enteritis respectively. They were recovered in 8 cases and 2 improved. The total effective rate of 173 cases was 93.06%. Bacteriological eradication was shown in all patients during one course of treatment except one case of S.typhimurium,one klebsilla pneumonae and ten gonorrhea.
The MIC90 of Enoxacin on dysentry, typhoid fever and colibacillus were less than 0.2 mg/L. The adverse effect was 4. 62%, none of the patients had to discontinue the treatment.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1989年第6期433-437,共5页
Chinese Journal of Antibiotics
关键词
氟啶酸
氟哌酸
菌痢
伤寒
抗菌药
Enoxacin
Norfloxacin
Dysentry
Typhoid fe ver
MIC(minimum inhibition concentration)
