摘要
ＢＴＦ２，又称ＴＦⅡＨ，为一多亚基蛋白质复合物，具有解链酶、依赖ＤＮＡ的ＡＴＰ酶及磷酸激酶活性，参与ｍＲＮＡ转录起始以及与转录偶联的核苷酸切除修复过程，在转录起始复合物形成过程中，ＢＴＦ２／ＴＦⅡＨ在有ＴＦⅡＥ存在时，可使ＲＮＡ聚合酶Ⅱ的羧端区域（ＣＴＤ）、ＴＢＰ及有关转录因子磷酸化．磷酸化反应可影响转录起始复合物中的蛋白质－蛋白质相互作用，调节转录起始，因此，ＢＴＦ２／ＴＦⅡＨ是一种重要的基本转录因子．
BTF2,also named TFⅡH,withmultiple subunit complex id believed to havehelicase,DNA-dependent ATPase and phos-phate kinase activities paticipated in transcrip-tion initiation and transcription -coulpled nu-cleotide-excision repair.During the formationof transcription initiation complex,poly-merase ⅡC-terminal domain(CTD),TBP andassociated transcription factors are phosphory-lated by BTF2/TFⅡH in the presence ofTFⅡE.These phosphorylation modificationscan be expected to have effects on the regula-tion of transcription initiation thrOugh affec-ting protein-protein interactions.So BTF2/TFⅡH is an important transcription factor ineukaryotic cells.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1995年第6期491-494,共4页
Progress In Biochemistry and Biophysics
