摘要
目的探讨婴幼儿哮喘患者血清超氧化物歧化酶（ＳＯＤ）及过氧化脂质（ＬＰＯ）含量的变化。方法病例对照研究。哮喘组４０例，分为急性期和缓解期，正常对照组３０例。采用放射免疫分析法测定血清中ＳＯＤ，用改良ＴＢＡ法测定血清中ＬＰＯ。对测定结果进行ｔ检验。结果哮喘组急性期、缓解期、对照组ＳＯＤ分别为４３２．６±１３９．３，７０６．１±１７７．３和９４６．７±２２３．２μｇ／Ｌ，ＬＰＯ分别为９．９３±２．８６，６．１２±１．５１和４．２４±０．７５ｎｍｏｌ／Ｌ。与对照组相比哮喘组急性期及缓解期ＳＯＤ均明显下降（Ｐ＜０．０１），ＬＰＯ均明显升高（Ｐ＜０．０１）。结论ＳＯＤ和ＬＰＯ在婴幼儿哮喘发病中起着重要作用，用抗氧化剂治疗哮喘可能有效。
Objective To search for the changes of superxide dismutase(SOD)and Lioperoxidation(LPO)in the Child patients with asthma.Methods Case-control research.There were 4 patients in asthma group and 30 normal persen in normal control group.The 40 patients in asthma group were divided into 2 groups:acute stage group and remission stage group.The serum SOD was determined by RIA, the LPO was determined by modified TBA method.The t-test was carried out for the results of determination.Results The values of SOD of acute stage.remission stage of asthma group and mormal control group are 432.6±139.3,706.1±177.3 and 946.7±223.2 μg/L respectively,and the values of LPO of the 3 groups are 9.93±2.86,6.12 ±1.51 and 4.24±0 .75 nmol/L.comparing with normal control group, the values of SOD of acute stage and remission stage of asthma group are obvious decreased (P<0 .01), but the values of LPO areobvious increased(P<0.01)Conclusion SOD and LPO play the important role in the Child patients with asthma.It may be effective to use anti-oxidant to treat the child patients with asthma.
出处
《实用儿科临床杂志》
CAS
CSCD
1995年第2期70-72,共3页
Journal of Applied Clinical Pediatrics
