摘要
对7例胰岛素抗体阳性及9例胰岛索抗体阴性的糖尿病人的胰岛素药物动力学研究表明,胰岛素抗体减缓胰岛素在体内的代谢速度,推迟达峰时间,升高最大浓度,加速胰岛素向组织的分布。二组患者胰岛素药物动力学参数如下(?±SD,阳性/阴性):α,1.35±0.46/0.817±0.522(h^(-1));β,0.142±0.088/0.416±0.091(h^(-1));Ka,1.50±0.61/2.19±0.71(h^(-1));Kel,0.138±0.084/0.496±0.068(h^(-1));Vc/F,69.7±34.6/178±42.3(L);AUC,2492±2188/171±50.7(h.mU/L);Cl/F,8.39±4.46/87.7±21.9(L/h);Tm,1.22±0.28/0.86±0.17(h);Cm,417±285/55.3±15.4(mU/L)。两组病人上述动力学参数均有显著性差异(P<O.05)。
Pharmacokinetics of insulin in 7 insulin-antibody-positivepatients and 9 insulin-antibody-negative patients, both with diabetes, hasbeen studied. The results show that insulin antibody (IAb) reduces therate of insulin elimination, delays the peak time, and raises peak concen-tration of insulin in serum. The rate of distribution to tissue in IAb-positive patients is higher than that in IAb-negative patients. The pharma-cokinetics parameters of the two groups are(mean±S. D., IAb-positive/IAb-negative); Alpha, 1, 35±0. 46/0. 817±0. 522(i/h); Beta, 0, 142±0. 088/ 0.416±0.091 (i/h); Ka, 1.50±0.61/2. 19±0.71 (i/h); Ke, 0. 138±0.084/0.496±0.068 (i/h); Vc/F, 69. 7±34.6/178±42. 3(L); AUC, 2492±2188/171±50. 7(h. mU/h); CL/F, 8. 39±4. 46/87. 7±21. 9 (L/h); Tm, 1. 22±0. 28/0. 68±0. 17(h); Cm, 417±285/55. 3±15.4 (mU/L). All these parameters betweer twogroups are statistically different.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1989年第4期221-225,共5页
The Chinese Journal of Clinical Pharmacology
关键词
糖尿病
药代动力学
胰岛素
抗体
diabetes
pharmacokinetics
insulin
insulin antibody
