摘要
通过对全反式维甲酸治疗的急性早幼粒细胞白血病25例长期随访,发现采用全反式维甲酸与化疗交替维持治疗者,1年存活率94％,2年存活率76.5％,3年为70.6％,30个月后呈平坦期,最长1例生存期已超过6年。单用全反式维甲酸维持治疗者,1年存活率50％,2年存活率37.5％。认为维持治疗时间以3年为宜,复发者的治疗以联合化疗为主,单用维甲酸效果不佳,同时认为重体力劳动和强烈精神刺激可能是导致复发的诱因。
Twenty-five cases of acute promylocytic leukemia (APL) were treated wilh all-Trans retmoie acid (ATRA) and a long-term follow-up of these cases was perfonned. Among them,the l year,2 year and 3 year survival rates were 94%,76. 5% and 70- 6% respectively for the patients who had received ATRA and chemotherapy alternatively for rnaintain therapy,the longcst survival duration was more than 6 years.The 1 year and 2 year survival rates were 50% and 37. 5% respectively for the patients who had received ATRA alone. The results indicated that the duration of continuation therapy must be longer than 3 years.and combination chemotherapy was suggested for the patients who had a relapse. The prognosis of patients using ATRA alone would be poor. Hard labour and strong psychic stimulation may be the factors resuhing in relapse.
出处
《天津医药》
CAS
1995年第5期279-281,共3页
Tianjin Medical Journal
关键词
全反式维甲酸
早幼粒细胞
白血病
药物疗法
疗效
all-trans retinoic acid acute promylocytic leukemia long-term follow-up
