摘要
对７９名ＨＢＶ标志阴性少年人群，以乙肝疫苗１０μｇ×３的免疫剂量和０、１、２月的免疫程序进行接种，对其抗－ＨＢｓ免疫应答和临床保护效果作了为期７年的定人随访。结果表明，抗－ＨＢｓ阳转率在免后三个月时为１００％，均值为３０８４ＭＩＵ／ｍｌ。至免后８４个月时疫苗接受者中仍有５５．７％的抗－ＨＢｓ水平≥１０ＭＩＵ／ｍｌ。６例检出抗－ＨＢｓ，其中５例的抗－ＨＢｓ持续处于高水平。全部观察对象无一例检出ＨＢｓＡｇ或发生临床肝炎。少年接种乙肝血源疫苗至少７年内可具有保护性抗体。故在此期内不需加强免疫。
Seventy-nine adolescents negative for HBV serologic markers have been received three doses of 10μg HBV vaccine derived from human plasma by a schedule of 0、1、2 month,and subsequently follow-up with immune response and clinical protection annually for seven years. The results showed that the positive rate of anti-HBs was 100% at three months with GMTs 3084mIU/ml level. Among these vaccinees ,six have developed the anti-HBc,Five kept the anti－HBs at high level persistently. None of them developed detectable HBsAg or clinical hepatitis. Immunization of adolescents with plasma-derived HBV vaccine has proved here to have protective immune activity that can prevent or modify primary infection for at least seven years,booster immunization is not necessary during this period.
出处
《微生物学免疫学进展》
1995年第4期193-196,共4页
Progress In Microbiology and Immunology
