摘要
三甲基甲硅烷基异恶唑的负离子与P－取代苄腈（2a）～（2e），反应制得的N－甲硅烷基－1－氮杂烯丙基负离子（3a）～（3e），在无水四氢呋喃存在下与过量查耳酮（4a）反应，生成相应的吡啶衍生物（5a）～（5e），回收率达40～70％．但从（3a）与肉桂醛（4b）以及甲基乙烯酮（4c）的反应结果分析，未能得到目的生成物（5f）和（5g）．前者只得到组成极复杂的反应混合物；后者则回收到（3a）的烯胺．
The preparation of five Pyridine derivatives(5a) ~ (5e)is reported. An N - silyl - 1 - aza-allyl anions (3a)- (3e) generated from N- silylcarbanion (1 ) of 3-methyl-5- (trimethylsilylmethyl)isoxazole and p-substituted benzonitrile (2a ) ~ (2e ) (R1=H.CH3,CH3O,CL,CF3 ).reacted with an excessive amount of chalcone(4a)in the presence of dry tetrahydyofuran to provide the corresponding five pyridine derivatives (5a ) ~ (5e ) in good yields(40.62. 52. 51, and. 70% respectively), but the same reaction of anion (3a ) and cinnamaldehyde (4b). methylvinyl ketone (4c) did not give the expectation result.
关键词
甲硅烷基
氮杂烯丙基
负离子
吡啶
酮
N-silyl-1-aza-allyl anions
Pyridine
α,β-unsaturated Ketone
N-heterocyclic compounds
