摘要
目的 研究单味大黄对急性胰腺炎的疗效与机理。 方法 单味大黄治疗水肿型胰腺炎428例,单味大黄制剂与复方西药随机对比治疗225例。重用单昧大黄加西医药治疗出血坏死型胰腺炎125例与单纯西医药治疗107例作回顾性对比。作动物模型及大黄对厌氧杆菌、内毒素血症、血液流变性的作用等研究。 结果 水肿型胰腺炎的有效率为100％,其中显效率达83.2％,各种大黄制剂疗效相似,但在腹痛消失、退热、尿淀粉酶恢复正常时间方面比复方西药优(P<0.01或0.05)。重用单味大黄加西医药治疗出血坏死型胰腺炎的手术率死亡率均比单纯西医药明显降低。大黄治疗后在电镜下观察到胰腺细胞的修复及紧密连接处恢复正常。另有抑制厌氧杆菌和内毒素吸收、解除微循环障碍等作用。 结论 单味大黄治疗急性胰腺炎优于同类中西药物,能缩短疗程,减少并发症,降低手术率与死亡率,具有“廉、简、验、便”的特点。大黄治疗急性胰腺炎的直接机理是对胰腺细胞具有保护作用。大黄对内毒素血症、血液流变学、前列腺素、血栓素及厌氧杆菌等多方面作用表明了防治急性胰腺炎的间接作用。
AIM To study on the efficacy and mechanism of rhubarb alone in the treatment of acute pancreatitis. METHODS 428 patients with acute edematous pancreatitis were treated with crude rhubarb alone, 225 patients with rhubarb plus western medicines. 125 patients with acute hem-orrhagic or necrotizing pancreatitis were treated with high dose alcoholic extract tablet of rhubarb plus ordinary western drugs. And 107 patients were treated with ordinary western drugs only.RESULTS The efficacy of rhubarb in the treatment of edematous pancreatitis was 100%, and it was 83.2% with good results, being better than that of western drugs. In the rhubarb therapy, the course was shorter (P<0. 01) with lower operation rate and mortality rate. It also had the merits of being cheap, convenient and achieving quick recovery. The alcoholic extract tablet of rhubarb can defend membrane of pancreatic cells from endotoxemia in animal models of a-cute pancreatitis.CONCLUSION Rhubarb is an excelent medicine in the treatment of pancreatitis.
关键词
胰腺炎
急性
大黄
pancreatitis acute rhubarb animal model
