摘要
高血压病、冠心病及糖尿病所致高粘血症８３例随机分为倍他司汀治疗组（男性２９例，女性２４例；年龄６０±ｓ６ａ）和羟乙基淀粉组（男性１４例，女性１６例；年龄５７±７ａ），均以５００ｍＬ静脉滴注，１４ｄ为一个疗程。结果：倍他司汀组能明显改善血液流变学和甲襞微循环，与羟乙基淀粉组无显著差别，未见明显不良反应。
Eighty-three patients with blood hyperviscosity caused by essential hypertension(32),coronary heart disease(25),and diabetes(26) were randomly divided into two groups:(A)53 patients(M29,F24;age 60±s 6 a) received betahistine 20 mg injection 500 mL.iv.drip,qd×14 d;(B)30 patients (M14, F 16;age 57±7 a) received hetastarch 500 mL,iv,drip,qd×14 d.Results showed that there were apparent decreases of whole blood viscosity,platelet adhesion rate,time of red blood cell electrophoresis(all P<0.05) indices of thrombosis in vitro,(P<0.01),and total score of nailfold microcirculation(P<0.01) in group A,but there was no significant difference between the two groups(P>0.05).The adverse reactions were mild.
出处
《新药与临床》
CSCD
北大核心
1995年第2期79-82,共4页
关键词
倍他司汀
羟乙基淀粉
高粘血症
血液流变学
betahistine
hetastarch
blood viscosity
rheology
microcirculation
