摘要
本文研制了三种硫酸锌缓释制剂—骨架型缓释片A、膜控型缓释片B及缓释微丸C,建立了锌的体外分光光度法。服用硫酸锌制剂前后的体内血浆锌浓用原子吸收分光光度法测定,将净增血浆锌浓按Ka=K带时滞的单室药动学模型,经计算机用Guass-Newton-Damping法处理求得药动学参数,血浆锌浓度拟合值与实测值一致。与市售硫酸锌糖衣片相比,A、B对大鼠及家兔胃的急、慢性刺激性大为降低,甚至小于葡萄糖酸锌胶囊。
Three sustained-release tablets consisting of an oral matrix (A), a membrane controlled-release tablet (B)and an encapsulated sustained-release pellets (C) were developed in order to reduce the gastrointestinal irritation upon administration. A spectrophotometry and an atomic absorption spectrometry in vivo for determination of zinc were established. The release constant in vitro (Kr) of A,B,C,D (an imported product of encapsulated sustained-release pellets) and E (a domestic commercial tablet) is 0.1155, 0.1695, 0.1473, 0.1932 and 2.6917 h^(-1) respectively, The determined data of the increased plasma zinc are well fitted to an one-compartment model with a lag time for absorption (Ka is equal to K). The pharmacokinetic parameters were estimated by using the nonlinear least square computer program.The bioavailability of A,B and C relative to D was 84.63 % 100.0 %,and 54.30 % respectively.The resultsof the gastric irritative tests on rat and rabbit have indicated that the new tablets A and B were shown to be significantly less irritative to gastric mucosa than E, B is better than A and even less irritative less than zinc gluconate capsules.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1989年第2期72-76,共5页
Journal of China Pharmaceutical University
关键词
硫酸锌
缓释片
Zinc sulfate
Sustained-release-tablets
Zinc determinations in vitro and in vivo
Dissolution
Pharmacokinetics
