摘要
关附甲素（ＧＦＡ）浓度为２０～３ｏμｇ·ｍｌ－１时，可以降低无Ｋ＋高Ｃａ２＋液灌流离体大鼠心脏诱发ＶＴ和ＶＦ的发生率。清醒大鼠ｉｖＧＦＡ２．５～１０ｍｇ·ｋｇ－１，可依剂量性显著增加北草乌头碱引起室性早搏的用量。清醒犬ｉｖＧＦＡ１０ｍｇ·ｋｇ－１，可逆转哇巴因引起ＶＴ，并对麻醉犬（１０～２０ｍｇ·ｋｇ－１），由ＡＣｈ诱发房颤有明显的抑制作用。ＧＦＡ１０ｍｇ·ｋｇ－１ｉｖ可明显减慢麻醉犬或清醒犬心率，对心肌收缩性（Ｖｍａｘ和Ｖｐｍ）只有轻度而短暂的抑制，但对左室收缩压，心搏量和心输出量无明显影响。
Guan-fu base A(GFA)is a terpenoid alkaloid isolated
from the tuber of Aconitumcoreanum in our institute. GFA(20～
30mg·L-1) reduced the ventricular tachycardia(VT)andventricular
fibrillation(VF) rate induced by K+ -free and high Ca2+ solution in
Langendorf heart ofrats. Pretreatment of conscious rats with GFA
2.5～10 mg· kg-1 iv, increased the amount ofbeiwutine necessary to
preduce arrhythmias. Ouabain-induced VT in conscious dogs was
reverted tosinus rhythm in 1～2min by iv GFA 9～10 mg· kg-1 . GFA
10～20 mg·kg-1 iv was also foundto be effective in protecting
anesthetized dogs from atrial fibrillation induced by topical
application of ACh. GFA 10 mg·kg-1 iv obviously decreased heart rate
and prolonged the P-R interval,but slightlyaffected the myocardial
contractility in anesthetized dog GFA showed no obvious effect on
strokevolume and cardiac output in conscious dogs.In conclusion, GFA
showed therapeutic and prophylactic effect on different models
ofexperimental arrhythmias without causing marked effect on
myocardial contractility.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第8期577-582,共6页
Acta Pharmaceutica Sinica
基金
国家"七五"攻关项目
关键词
关附甲素
心律失常
心肌收缩性
心输出量
Guan-fu base A
Arrhythmia
Myocardial contractility
Cardiac output
