摘要
用肾性高血压左室肥厚（ＬＶＨ）大鼠模型，观察了间硝地平（ｍ－Ｎｉｆ）和硝苯地平（Ｎｉｆ）长期给药（ｉｇ２０ｍｇ·ｋｇ－１·ｄ－１持续９周）对左室舒张功能、左心室肌和大脑线粒体及血管钙含量的影响。与假手术组相比，ＬＶＨ组左室顺应性明显下降，僵硬度增高，左心室肌和大脑线粒体及尾动脉和主动脉钙含量增加。与ＬＶＨ组相比，ｍ－Ｎｉｆ和Ｎｉｆ各组左室顺应性改善，僵硬度降低（Ｐ＜０．０１），左心室肌线粒体及尾动脉和主动脉钙含量较ＬＶＨ组显著降低（Ｐ＜０．０１）。两药在作用强度上无显著差异。
Left ventricular hypertrophy
(LVH)was induced by renal hypertension in rats. m-Nifedipine(m-Nif,
ig 20 mg·kg-1·d-1 for 9 wk)decreased LV weight in the renovascular
hypertensive rats(P<0.01).The LV compliance in LVH group was
significantly decreased compared with that in sham-operated group.The
LV stiffness constant,Ca2 + content in left ventricular myocardial
and cerebral mitochondrin, aorta,and tail artery were markedly
raised.m-Nif could markedly reduce the LV stiffness constant,improve
the LV compliance,and decrease the Ca2+content of left ventricular
myocardial mitochondria and tissues of artery from LVH rats. These
effects of m-Nif were similar to those of nifedipine at the same
dosage.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第1期6-11,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
间硝地平
硝苯地平
肾性高血压
左室肥厚
钙
m-Nifedipine
Nifedipine
Renovascular
hypertension
Left ventricular hypertrophy
Left ventricular diastolic
function
Calcium
