摘要
从中药牛膝中提取得到的一种新多糖化合物一牛膝多糖，用不同的硫酸化试剂合成牛膝多糖硫酸酯。研究了最佳反应条件，其产物水溶性好，呈中性，最高产率达８２．１１％，取代度（Ｄｓ）···达到三以上，硫含量达２１％以上。根据牛膝多糖的分子结构，多糖分子中的羟基已最大限度地被酯化。体外抗病毒试验初步表明牛膝多糖硫酸酯有很强的抑制乙型肝炎病毒ＨＢｓＡｇ和ＨＢｅＡｇ的活性，对Ｉ型单纯性疱疹病毒也有明显的抑制力。
Sulfation of Achyranthes bidentata polysaccharide (Abps)with
sulfuric acid or sulfurtrioxide-pyridine or chlorosulfonic
acid-pyridine was studied.A homogeneous sulfation method withgood
yield of 82.11%was obtained, using chlorosulfonic acid in an excess
of pyridine. SulfatedAchyranthes bidentata polyaccharide was obtained
as an amorphous sodium salt easily souluble in water. The UV and IR
specttum of Abps sulfate showed absorptions at 208, 268, 286 nm and
1232,823. 6 cm-1 respectively. The sulfur content of the products was
found to be 20～22%. The degreeof suhtitution varied from 2. 8 to
3.2. It showed that the hydroxy group of Abps was almostcompletely
esterified by chlorosulfonic acid. The Abps sulfate was shown to have
high activity as anti-HBsAg and HBeAg. It is also effectiveon simple
herpes virus type-I.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第2期107-111,共5页
Acta Pharmaceutica Sinica
关键词
牛膝多糖
多糖硫酸酯
抗病毒
合成
牛膝
Achyranthes bidentata polysaccharide
Polysaccharide sulfate
Antivirus
