摘要
抗癌药物的研究：４－氯苯氧乙酰胺衍生物的合成李兰敏，徐世平（中国医学科学院，中国协和医科大学药物研究所北京１０００５０）在抗癌领域里，人们曾利用除莠剂能杀灭杂草而不伤害禾苗，有的甚至在杀灭杂草的同时还能刺激作物的生长这一选择作用，探索该类化合物抗癌的...
Since compounds Ⅲ and Ⅳ possess retinoid-like action
and analogues of Ⅰ inhibit some cancer cells ,seventeen derivatives
of chlorophenoxy acetamide were synthesized.Of the seven compounds
screened ,two exhibit cytostatic activity(1 and 2).Mass spectra
showeda special expulsion of SO2 and CO from the sulfonamide
compounds,Nuclear magnetic resonancesplitting patterns of these
compounds also showed interesting features.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第7期556-560,共5页
Acta Pharmaceutica Sinica
关键词
抗癌药
合成
氯苯氧乙酰胺
衍生物
Cancer
chemoprevention
Chlorophenoxy acetamide
Differentiation induction
