摘要
观察了丁基苯酞（ＮＢＰ）对小鼠全脑缺血脑保护作用和脑能量代谢的影响。用Ｌｏｗｒｙ法测定脑乳酸，ＡＴＰ和磷酸肌酸（ＰＣｒ）的含量。结果表明，ＮＢＰ１１２．５或２５０ｍｇ·ｋｇ－１ｓｃ能明显延长断头或ｉｖ饱和ＭｇＣｌ２后喘息的时间；ＮＢＰ１５Ｏ或２００ｍｇ·ｋｇ－１ｓｃ能明显减少断头缺血后乳酸的升高和ＡＴＰ及ＰＣｒ的降低。实验结果提示，ＮＢＰ对缺血脑有保护和改善脑能量代谢的作用。
The effects of NBP on gasping and brain energy metabolism after
complete brainischemia in mice subjected to decapitation were in
vestigated. The levels of ATP ,phosphocreatine(PCr)and lactate were
determined by the method of Lowry. The data indicated that NBP at
112.5 or250 mg· kg-1 sc can significantly prolong the duration of
gasping and at the dose of 150 or 200mg· kg-1 sc reduce the level of
lactate and increase the levels of ATP and PCr after complete
brainischemia。The results suggest that NBP may have brain protective
action and improve ischemic brainenergy metabolism.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第10期741-744,共4页
Acta Pharmaceutica Sinica
基金
国家科委新药研究基金
