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灰树花多糖促进干扰素诱生作用的研究 被引量:12

ENHANCEMENT OF MOUSE INTERFERON INDUCTION IN VIVO BY GRIFOLAN OLYSACCHARIDE
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摘要 灰树花多糖以2000,100O,500mg/kg/d的剂量给NIH小鼠灌胄7天,然后腹腔注射1280HAU/ml的NDV(新城鸡瘟病毒)0.5ml。6h后放血,分离血清,以L929细胞、VSV病毒检测鼠干扰素。结果发现,灰树花多糖能够促进NDV诱生干扰素。各实验组、NDV对照组和生理盐水对照组的干扰素活性分别为44.5,45.0,29.0,12.0和2.0U/ml,据此认为,灰树花多糖抗病毒感染的作用可能由干扰素系统介导,但也可能有其他机理参与。 NIH mice were orally fed by intubating Grifolan polysaccharide at the dose of 2000,1000,and 500 mg/kg of body weight daily for 7 days.They were injected with 0.5 ml of NDV(Newcastle disease virus)suspension containing 1280 HAU/ml(hemagglutination units).After 6hours the mice were bled and their sera assayed.for the production of interferon.The murine sera were assayed on L 929 cells and VSV.It wasfound that the Grifolan polysaccharide was able to enhance the production of interferon induced by the NDV.The interferon activity of the three test groups and NDV, saline injected controls were 44.5,45.0,29.0,12.0 and 2. 0 U/ml respectively.These results suggested that the protective effects of Grifolan polysaccharide against virus infection might be mediated by the interferon system. However,other mechanisms might also be involved.
出处 《浙江医科大学学报》 CSCD 1995年第6期257-259,共3页
关键词 灰树花多糖 干扰素诱导剂 干扰素 正粘病毒 Grifolan polysaccharides/drug eff Interferon inducers Interferons/biosyn Mice
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