摘要
本实验在自发性高血压大鼠（ＳＨＲ）观察了卡托普利对血压，心肌和主动脉组织ＡＴⅡ，ＥＴ，ＤＡ，ＮＥ的影响。结果表明，ＳＨＲ心肌、主动脉组织ＡＴⅡ、ＥＴ含量显著增加，而ＤＡ、ＮＥ含量则呈消耗性减少。卡托普利治疗能降低ＳＨＲ，心肌、主动脉ＡＴⅡ、ＥＴ含量，增加ＤＡ、ＮＥ含量，同时显著降低大鼠血压。提示卡托普利的降压作用机制可能与抑制心肌、血管组织ＡＴⅡ、ＥＴ、ＮＥ和ＤＡ的生成和释放有关。
Changes of blood pressure and angiotensinⅡ endothelin,noradrenalineand dopamine(ATⅡ,ET,DA,NE)of myocardium and aorta were observed in spon-taneously hypertensive rats(SHR)treated with captopril.The results showed that in SHR,the contents of ATⅡand ET increased,but that of DA and NE decreased due to theirconsumption,Captopril decreased the contents of ATⅡ, ET and raise the contents ofDA,NE,and also lowered the blood pressure in SHR. It was suggested that the hypo-tensive effect of captopril might be mainly due to its inhibitory effect on producing andreleasing of ATⅡ,ET,NEand DA in vasocardiac tissues.
出处
《中国病理生理杂志》
CSCD
北大核心
1995年第3期308-310,共3页
Chinese Journal of Pathophysiology
