摘要
用犬失血性休克模型观察高频喷射通气（ＨＦＪＶ）给氧对犬血中单胺类递质及组胺的影响。结果表明，在ＨＦＪＶ下动脉血中的去甲肾上腺素（ＮＥ）、多巴胺（ＤＡ）、５－羟色胺（５－ＨＴ）及组胺水平均低于对照组（Ｐ＜０．０１），存活时间明显延长（Ｐ＜０．０１）。提示存活时间延长与ＨＦＪＶ后，交感－肾上腺髓质系统兴奋降低，单胺类递质释放减少及同时抑制了肥大细胞释放组胺有关。实验还观察到：休克晚期ＮＥ、ＤＡ、５－ＨＴ的水平显著下降，而组胺则升高，这可能与单胺类递质的耗竭和抑制有关。
The effect of HFJV with oxygen on the monoamine transmitter and hista-mine in blood were observed in dog model of hemorrhagic shock.The results showed thatthe contents of NE,DA,5-HT and histamine in arterial blood were decreased(P<0.01)and the surviving times were prolonged by HFJV,It is suggested that the prolonged sur-viving times is related to deereased release of monoamine transmitter under lowered exci-tation of sympathoadrenomedullary system along with it,histamine release by basophillcells were inhibited after HFJV.The levels of NE, DA,and 5-HT were reduced signifi-cantly,but during the later period histamine was raised.It may be related to histalninestimulated H_2-receptor of presynaptor of adrenergic fiber, which inhibited the release ofmonamine transmitter.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1995年第3期276-280,共5页
Chinese Journal of Pathophysiology
