摘要
采用灵敏的ＩＲＭＡ法在贵阳、凯里、都匀三地区五年内筛查了２４０４０例新生儿滤纸血斑ＴＳＨ水平，以监测贵州省ＩＤＤ。各年度三地区ＴＳＨ分布频率大致相似，均向高值方向偏移。其ＴＳＨ＞５ｍＵ／Ｌ者为３３．７～５１．０％之间。高于富碘国家水平，表明三地区有缺碘存在。且贵阳、凯里ＴＳＨ＞５ｍＵ／Ｌ者有逐年上升趋势，与此同时，三地区学生甲状腺肿大率也有上升趋势。尿碘＜１００ｕｇ／Ｌ者和居民碘盐含碘量＜２０ｍｇ／ｋｇ者的百分比率都较高。结果表明，新生儿ＴＳＨ筛查是监测ＩＤＤ最敏感和有效方法。
TSH levels were determined of 24040 newborns in Guiyang,Kaili and Duyun,using IRMA on filter paper blood spot,in the past 5. years for monitoring of IDD in Guizhou province. The results showed similor frequency distribution at different levels of TSH in the three areas,with a marked drift towards high level. The percentages of neonates with TSH level greater than 5 mIU/L 33. 7 %～ 51. 0 %, which were obviously high as compared with those in iodine sufficient countries,and these indicated that iodine deficiency remained a problem in the three areas. The percentages of neonates with TSH level greater than 5 mIU/L also demonstrated an increasing trend year by year associated with the goitre rate of schoolchildren in Guiyang and Kaili. The percentages of subjects with urinary iodine level less than 100ug/L. and the inhabitants ingested salt with less than 20mg/kg were relatively high. The results suggest that neonatal TSH measurement is the most sensitive and reliable indicator for monitoring IDD.
出处
《中国地方病学杂志》
CAS
CSCD
1995年第1期1-4,共4页
Chinese Jouranl of Endemiology
