摘要
以饮用高氟水的方法制造了雌性小白鼠慢性氟中毒模型。观察了氟中毒授乳小白鼠所哺育的仔鼠生长情况,以荧光分光光度法测定了氟中毒授乳小白鼠脑组织5—羟色胺(5—HT),5—羟吲哚乙酸(5—HIAA)和多巴胺(DA)的含量。结果不论仔鼠是否由对照组或实验组母鼠所生,只要其生后由对照组授乳鼠来哺育,则其体重增长情况正常;不论仔鼠是否由对照组或实验组所生,只要其生后由实验组授乳鼠来哺育,则其体重增长则显著落后。上述结果揭示:(1)慢性氟中毒可抑制小白鼠泌乳功能;(2)慢性氟中毒授乳小白鼠脑组织5—羟色胺和5—羟吲哚乙酸有降低趋势,而多巴胺则有升高趋势。—羟色胺和5—羟吲哚乙酸有降低趋势,而多巴胺则有升高趋势。
Animal model of chronic fluorosis in female mouse was developed with drinking water containing high fluoride. The growth change of pups feed by lactating mouse with chronic fluorosis was observed and the content of 5-HT ,5-HIAA and dopamine in brain tissue of lactating mouse with chronic fluorosis were determined with fluospectrophotometry. The results were as follows: whether borne from control or experimental group mothers after birth the increases in body weight of all pups so long as feed by lactating mouses of control were normal and whether borne from control or experimental group mothers after birth the increases in body weight of all pups so long as feed by lactating mouses of experimental group were retarded significantly. The results mentioned above suggest the lactation might be inhibited by chronic fluorosis in mouse;the contents of serotonin and 5-HIAA in brain tissue of lactating mouse with chronic fluorosis show a tendency of decrease and the contents of dopamine show a tendency of increase.
出处
《中国地方病防治》
北大核心
1995年第4期202-203,共2页
Chinese Journal of Control of Endemic Diseases
