摘要
用低钙偏食饲料饲养大鼠,经饮水投氟复制软化型氟骨症动物模型,并在饲料中分别补充钙、维生素C、鱼肝油及酪蛋白,重点观察胫骨的形态学改变,辅以血钙、ALP及骨钙测定。实验结果表明,软化型氟骨症以骨转换增强为特点,骨形成与吸收均很活跃,软化与疏松并存。在本实验条件下,4种营养成分中以钙对氟的骨骼毒性拮抗作用最强,鱼肝油次之,维生素C及酪蛋白几乎无作用。
An experimental model of osteomalacia skeletal fluorosis was produced in rats kept on a monotomous diet of low Calcium and drinking water supplemented excess fluoride (100mg/L F-),and the nutrition factors were added separated to the diets,including Calcium,VitaminC, Cod-fish-liver and Casenin. Then the morphological changes of tibiae were observed,and some biochemical and metabolic changes were examinated.The result showed that osteomalacic skeletal fluorosis is characterized by bone turnover accelerated, both formation and resorption is active,osteomalacia and osteoporosis exist at the same time. The Calcium had the best effect to resist the fluoride toxicity on skeleton among several nutrition factors. There were no effects when VitaminC and Casenin were added. Cod-fish-liver has effective to some of rats and no to some.
出处
《中国地方病防治》
北大核心
1995年第6期323-325,共3页
Chinese Journal of Control of Endemic Diseases
基金
自然科学基金资助项目
项目号:39470633
