摘要
轻度缺碘时缺硒或补硒可明显降低或增加大鼠组织硒含量和谷胱甘肽过氧化物酶（ＧＰｘ）活力，但随时间的延长各组织变化趋势不同。在４周内肝脏和肾硒含量和ＧＰｘ活力变化幅度大，在８周时红细胞的硒含量和ＧＰｘ活力仍有继续增加或降低的趋势。大脑和甲状腺硒含量和ＧＰｘ活力缺硒后反而升高，但增加幅度明显低于补硒后的增加幅度。提示大脑可优先得到硒，大脑和甲状腺具有较强的维持抗氧化状态的能力。肝脏、肾脏和红细胞可能分别是硒缺乏早期和后期重要器官硒的主要来源。红细胞可能起“硒储备库”的作用。
Abstract: Se contents and glutathione peroxidase (GPx) activities in tissues of rats with mild iodine deficiency increased and decreased after the repletion and the depletion of selenium (Se) respectively, but the changed tendencies in various tissues was different with time prolonging. Within four weeks, hepatic and renal Se contents and GPx activities changed more, and at the 8th week there was the tendency of further increase and decrease in RBC′s Se content and GPx activity in Se-repleted and Se-depleted rats, respectively. On the contrast, Se content and GPx activities in brain and thyroid after the depletion of Se were increased, but the increased extent was less than that after the repletion of Se. These results suggest that brain has the priority to get Se. Brain and thyroid have better ability in the maintaince of antioxidant status. Liver and kidney or RBCmay be the essential sources of Se for the important organs during the early or later Se-deficient stage, respectivily. RBC may act as "Se pool".t Seleium Iodine; Glutathione peroxidase
出处
《中国地方病学杂志》
CSCD
1995年第4期193-196,共4页
Chinese Jouranl of Endemiology
基金
国家"八五"项目
