摘要
培氟沙星（ＰＦＬｘ）８２１例临床观察，不良反应发生率为１１．１％，主要表现为消化道反应，其次为皮疹，多数病人程度不重，可以耐受。０．２、０．３ｇ每日２次服用，可明显降低不良反应发生率及严重程度。本实验扩大了Ⅱ期临床验证的病种和年龄，痊愈率为６５．７％，有效率为９２．５％。９７例老年及３１例肝肾功能不全病人的临床观察证实，ＰＦＬＸ对以上病人安全可靠。因观察时间不够长，而ＰＦＬＸ经肝代谢，对有明显肝功能不全者，慎用为宜。
The clinical efficacy of 821 cases of various bacterial infections treatedwith pefloxacin(PFLX)was reported.Adverse drug reaction rate was 1 1.1%. Adverseeffects included gastrointestinal disorders predominantly.and rash secondly. Most reactionswere lnild and well tolerated. Treating patients with one 0. 2 or 0.3g oral dose twice a daycould obviOusly reduce the rates and severity of adverse reactions. This clinical study extendranges of bacterial infections and ages. The total cure rate and effective rate was 65.7%and92.5%respectively. The investigation of 97 cases of elderly and 31 cases of hepatic or renalinsufficiency patients confirmed that PFLX was safety for these subjects. Because theduration of observation was short and the PFLX was chiefly metabolized through liver. patients with evident hepatic dysfunction should use PFLX carefully.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第2期144-147,共4页
Chinese Journal of Antibiotics
关键词
培氟沙星
细菌感染
临床评价
药物副作用
Pefloxacin. Bacterial infections.Clinical evaluation. Adverse effects
