摘要
为弥补现行进化理论的不足,我们广泛分析了大量现存的序列数据,相继总结出四种分子进化规律,即造血免疫生长因子的发育相关进化,细胞活性因子与受体的协同进化,mRNA编码区与非翻译区的协调进化及物种演化中的分子减速进化;首次提出“分子偶联”的进化学说;推断并证实:造血细胞生成素受体的发育相关进化、CD40配基与肿瘤坏死因子同源(此结果纠正了美国同行的错误结论)、相互作用蛋白质间的协同进化、造血免疫早期细胞分化因子的序列多态性。根据上述规律与学说,提出了发展我国基因工程多肽药物的战略性建议和寻找新型细胞活性因子的理论原则。上述工作预示,利用大量现存数据进行理论综合的时机正在生命科学领域逐步成熟。理论综合既是生命科学突破的希望所在,也是我国学者奋起的契机。
In order to remedy the defects of curent evolutionary theories, we analysed a great amount of sequence data stored, found the four principles of molecular evolution:development-related evolution of hemopoietic growth factors, concerted evolution between cytokines and their receptors, modulated evolution between coding regions and non-translated regions of rnRNAs, and slow-down evolution during phylogeny; put forward the evolutionary theory of molecular match; raised the following pre-
dictations and verified them: development-related evolution of hemopoietin receptors, homology be-
tween CD 40 ligand and tumor necrosis factor which corrected the false conclusion made by American scientists, concerted evolution between interacting proteins and sequence polymorphism of early ho-mopoietic cell differenting factors; on the basis of these principles and the theory, proposed our suggestions about the development of recombinant peptide drugs in our country and theoretical guide to look for and clone unkown cytokines.
出处
《中国科学基金》
CSCD
1995年第2期9-16,共8页
Bulletin of National Natural Science Foundation of China
基金
国家自然科学基金
863计划资助
关键词
分子进化规律
达尔文学说
分子进化学说
Principles of molecular evolution, Evolutionary theory of molecular matching, Neutral theory, Darwinian theory
