摘要
应用Horowitz’s有机溶剂/表面活性剂(S/D)对血液制品中病毒进行灭活。在三种凝血因子制剂(抗血友病因子Ⅷ,凝血酶原复合物,纤维蛋白原)中加入两种指示病毒(HSV-1和乙脑病毒)。结果证明S/D法对于易变性的血液衍生物中脂包膜病毒的灭活非常有效并且可行。
HSV-1 and Japanese encephalitis virus using as indicators were added inblood coagulation factors (antihemophilic factorⅧ, prothrombin and fibrinogen) and inactivat-ed by Horowitz's solvent/detergent (S/D) method. The result proved that S/D method wassignificantly effective and feasible in the inactivation of lipid-enveloped viruses in labile plas-ma piotein derivatives.
出处
《中国生物制品学杂志》
CAS
CSCD
1995年第3期105-106,118,共3页
Chinese Journal of Biologicals