摘要
本文收集腹腔镜或手术证实为子宫内膜异位症Ⅲ、Ⅳ期患者45例,随机分成三组,分别应用丹那唑、他莫西芬和丹那唑加他莫西芬联合治疗。随访临床治疗效果并测定外周血淋巴细胞(PBL)中IL—2诱生水平和 T 细胞亚群分析。结果表明,丹那唑联合他莫西芬治疗效果好,副作用少,优于单独应用丹那唑或他莫西芬治疗。子宫内膜异位症患者 PBL 中 IL—2诱生水平和 CD_4^+/CD_^+值明显高于对照组(P<0.01);丹那唑、他莫西芬治疗后 IL—2诱生水平和 CD_4^+/CD_^+值明显下降(P<0.01).说明子宫内膜异位症患者体内有细胞免疫功能和平衡状态的异常,丹那唑和他莫西芬有免疫抑制作用。
Forty-five patients with stage Ⅲ or Ⅳ endometriosis as diagnosed by either laparotomy or laparoscopy were randomized into three groups to study the efficacy of different therapeutic regimens.Group Ⅰ(n=15)was given oral danazol 200mg three times daily;Group Ⅱ (n=15)was given oral tamoxifen 10mg twice a day; Group Ⅲ had a combination of the two drugs,i.e. danazol 200mg twice daily plus tamoxifen 10mg per day.Induction level of interleukin-2(IL-2)andT cell subpopulations of the peripheral blood lympho- cytes(PBL)were determined before,during,and af- ter the 3 month treatment.Results indicated that com- bination of danazol and tamoxifen was more effective than the other two regimens and had less complica- tions.The induction level of IL-2 and the value of CD_4+/CD_^+ in PBL of the patients were markedly higher than those of normal control group(P<0.01). After the treatment with danazol or tamoxifen,IL-2 induction level and CD_4^+/CD_^+ were significantly re- duced(P<0.01).The results indicated that patients with endometriosis had immunologic dysfunction or imbalance;Danazol and tamoxifen had immunosuppre- sive and immunoregulatory effects.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
1995年第1期29-31,共3页
Chinese Journal of Practical Gynecology and Obstetrics
