摘要
代表自体免疫的自家抗体:抗甲状腺微粒体抗体(TMA)及抗甲状腺球蛋白抗体(TGA)在自体免疫性甲状腺炎(AIT)中的阳性率可达95％以上。作者对364例经穿刺证实之AIT患者分析,结合1978年Yoshida等70例尸检资料,认为凡有上述二抗体之一阳性,不论水平高低,在排除少数几种也可有抗体阳性但具有临床典型表现而易于鉴别的其他甲状腺病,本病诊断即可成立。据此诊断标准,对5000余人进行普查,发现上海地区的一般人群AIT患病率为5.2％。
As the name suggests, autoimmune or chronic lymphocytic thyroiditis (AIT or CLT) is a disease of thyroid autoimmune inflammation whatever the lesion is diffuse or focal, the thyroid is enlarged or not. It was recognized that in nearly all the AIT patients the thyroid microsomal antibody (TMAb) and/or thyroid thyroglobulin antibody (TGAb) were positive. The further analysis on thyroid needle aspirations of 364 AIT cases in our clinic and the data of Yoshida from 70 cases of autopsy revealed that the TGAb and TMAb were closely correlated with the presence of thyroid lymphocytic infiltration even the liter was as low as 1:20. Therefore we suggested that the diagnosis of AIT could be based on the positive findings of the above-mentioned autoimmune antibodies, whatever the level might be. Certain thyroid diseases which may also have positive TGAb and TMAb could be easily excluded by their clinical mcnifestations. With this diagnostic criterion, we investigated a population of 5000 in Shanghai and found an incidence of
5.2%
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1989年第2期67-69,共3页
Chinese Journal of Endocrinology and Metabolism
