摘要
用放射配体结合法测定３６例多器官衰竭（ＭＯＦ）患者血白细胞糖皮质激素受体（ＧＣＲ）和血浆皮质醇（Ｆ）的变化，并行ＡＰＡＣＨＥⅡ评分。结果：①ＭＯＦ患者ＧＣＲ为１１９４８±１０８８．９位点／细胞，明显低于正常人４５２６．６±４５２．６位点／细胞（Ｐ＜０．０１）；其下为７６７．２８±４３０．５６ｎｍｏｌ／Ｌ，高于正常人３５３．２８±１１５．９２ｎｍｏｌ／Ｌ（Ｐ＜０．０５）。②ＭＯＦ患者衰竭器官数与ＧＣＲ、ＡＰＡＣＨＥⅡ关系密切，与Ｆ浓度无关。③ＭＯＦ患者ＧＣＲ下降与下浓度升高关系亦不大。作者认为合理使用外源性糖皮质激素或提高ＧＣＲ水平有益ＭＯＦ的防治。
Glucocorticid receptor(GCR) of leukocytes in pe-ripheral blood and plasma
cortisol(F)concentrationwere determined by the method of radioligand bindingassay with[￣3H]
dexamethesone ( Dex)in 36 patientswith muItiplc organ failure(MOF). Acute Physiologyand
Chronic Health Evaluation (APACHE)Ⅱscoreswere used in these patients. The results revealed
thatGCR in MOF patients was 11 94.8±1088. 9 sites/cellwhich was markeadly lower than that in
normal controls(4526.6±451.3sites/ceLL)(P<0. 01).F concentrationin MOF patients was
￣·767. 28±430. 56 nmo1/L whichwas higher than that in normal controls(353.28±115. 92
nmol/L)(P<0.05). The number offailed or-gans was closely related to GCR and APACHE Ⅱ
scoresbut not related to F level in MSOF patients。There wasno significant relationship
between the decreased GCRand increased F concentration in MOF patients. The au-thors
consider that the reasonable use of exogenous glu-cocorticoid or measures to increase GCR
may benefit theprevention and treatment of MOF.
出处
《中国危重病急救医学》
CAS
CSCD
1995年第6期371-373,共3页
Chinese Critical Care Medicine
