摘要
在同等条件下，比较了粉防已碱（Ｔｅｔ）与维拉帕米（Ｖｅｒ）对大鼠血小板功能和红细胞变形力作用的异同。对ＡＤＰ诱导血小板聚集的抑制作用，Ｔｅｔ强于Ｖｅｒ４．８倍，对胶原诱导聚集的抑制作用，两药作用强度接近。Ｔｅｔ抑制血小板ＴＸＢ。产生作用强于Ｖｅｒ５倍。Ｔｅｔ抗血栓形成作用比Ｖｅｒ强１．２倍。提示，Ｔｅｔ抗血小板作用强于Ｖｅｒ。Ｔｅｔ提高红细胞变形力作用弱于Ｖｅｒ１．５倍，但两药加大剂量均能降低红细胞变形力。
The observation showed that Tet's Potency inhibiting ADP-induced Platelet aggregation was 4.8 times as strong as that of Ver,while both drugs was apProximate in the inhibition of collagen-induced platelet aggreption.The inhibitory effects of Tet on the formation of thrombus and the production of TXB2 were 1.2 times and 5 times as strong as that of Ver respectively.The efficacy of Tets increasing deformability of red blood cells was 1.5 times weaker than that of Ver.But increasing doses of both drugs decreased the erythrocyte deformability.Dept of Pharmacology Institute of Medical and Pharmaceutical Sciences Tianjin 300070
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第4期335-337,共3页
Chinese Pharmacological Bulletin
关键词
粉防己碱
维拉帕米
血小板聚集
红细胞变形力
tetrandrine
verapamil
platelet aggregation
TXB2 generation
thrombus formation
erythrocyte deformabiliy
