摘要
NHE-2已在裸小鼠皮下连续传至20代,移植成功率100％,宿主生存时间94±13.6天。移植瘤呈进行性增殖,第四周为肿瘤细胞DNA合成最旺盛期。形态学见胶质微丝,纤毛和空心菊形团样结构。PAP免疫组化,GFAP(+)。染色体以超过一倍体为主,异常染色体出现率10/10。移植瘤半体内试验,^(60)Co照射的致死量≥5Gy。
Human ependymoblastoma xenotransplanted into nude mice model (NHE-2) was established. The rate of success in initial transplantability was 4/5 and on subsequent serial transplantation of 20 passage were 100% in more two years.The survival time of host was 94±13.6 days. By light and electronmicroscopic examination, PAP immuno-peroxidase labelling GFAP and chromosome analysis,the characters of transplanted tumor were coincide with human ependymoblastoma.Some radio-biological research in the NHE-2 model were studied also.
出处
《中华神经外科杂志》
CSCD
北大核心
1989年第1期27-31,共5页
Chinese Journal of Neurosurgery
