摘要
利用大鼠左大脑中动脉电凝梗塞模型，在梗塞后不同时间测定脑组织含水量、总钙与Ｃａ２＋－ＡＴＰ酶的变化。脑梗塞后６小时病灶侧脑组织含水量已有明显增加，同时脑组织总钙亦增高，但是Ｃａ２＋－ＡＴＰ酶活性降低，至手术后４８小时达最峰值。术后１０天用暗环境被动回避试验作为行为指标，该模型出现学习记忆障碍，本实验结果为治疗脑梗塞和学习记忆障碍提供了依据。
In this study,using the model of middle cerebral artery occlusion(MCAO) ,the contents of brain's water,calcium and Ca2+-ATPase's activity were determined in different time after cerebral ischemia. We found the contents of water and total calcium in the damaged side of brain increased 6h after cerebral ischemia compared with the controls,but the activity of Ca2+- ATPase decreases. These changes reach to maximum 48h after ischemia. Dark environment avoidance test is used as index of behavior. We found rats expressd learning and memory disorder in 10 days after cerebral ischemia. These results suggest rat's nerve cells have calcium overload following cerebral ischemia, which. leads to learning and memory disorder. This study provides the bases for treatment of cerebral ischemia and learning and memory disorder.
出处
《中国行为医学科学》
CSCD
1995年第3期123-125,共3页
Chinese Journal of Behavioral Medical Science
关键词
脑缺血
学习
记忆
脑水肿
钙
病理
Cerebral Ischemia. Brain edema. Calcium. Learning and memory.
