摘要
氨茶碱涂膜剂为一种新颖的骨架型经皮给药系统。采用离体鼠皮进行该涂膜剂的体外渗透试验，并用组胺－乙酰胆碱引喘试验考察其平喘作用。结果表明，涂膜剂中氨茶碱以零级动力学经皮吸收；０～１２ｈ累积渗透量为４０．４％，渗透速率７７．６８μｇ／ｃｍ２·ｈ，本品有显著平喘作用，其作用优于氨茶碱溶液剂。
An Aminophylline film was developed and its transdermal release rate on mice skin was determinated.The permeation of aminophylline in the film through the mice skin followed zero-order kinetics.The permeation rate was 77.68μg/h·cm2.This film showed a remarkable therapeutic effect on asthma.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1995年第2期81-83,共3页
Journal of China Pharmaceutical University
关键词
氨茶碱
涂膜剂
经皮吸收
体外渗透
平喘药
Aminophylline
Film
Transdermal absorption
in vitro permeation
