摘要
目的:观察吡喹酮对21-d童虫皮层的作用.方法:小鼠于感染日本血吸虫尾蚴达21 d时,ig1剂吡喹酮,并在治疗后1-48 h的不同时间内剖杀取虫,作扫描电镜观察.结果:吡喹酮的剂量为300 mg·kg^(-1)时,宿主体内的21-d童虫示有轻度或中度的皮层褶嵴肿胀、融合、糜烂或破溃,且以盘状感觉器的肿胀为特征.用吡喹酮的较高剂量500 mg·kg^(-1)治疗,虫的体表亦有相似的变化,但较广泛和严重.若每d ig吡喹酮500 mg·kg^(-1),连给3 d,则虫的皮层严重肿、糜烂和剥落,并伴有宿主的白细胞附着.结论:结果表明,吡喹酮对21-d童虫有直接杀死作用.
AIM:To study the effect of praziquantel (Pra) on the tegument of 21-d-old schistoso-mula, mice infected with Schistosoma japon-icum cercariae for 21 d were treated ig with Pra at a single dose. METHOD: Groups of mice were killed at different intervals within 48 h, and the worms were collected by perfu-sion for scanning electron microscopic observation. RESULTS: When the dose used was 300 mg.kg-1, the worms showed mild or moderate swelling, fusion or even erosion and collapsed of the tegumental ridges, which was characterized by swelling of the discoid sensory structures. At higher dose of 500 mg .kg-1, similar alterations in the worm surface were seen, but more extensive and serious. When Pra 500 mg.kg-1 was given daily for 3 d, severe swelling, erosion and peeling of the tegument accompanied by the attachment of the host leukocytes on the damaged surface were seen. CONCLUSION: Pra exhibited a direct killing effect on 21-d-old schistosomula.
出处
《中国药理学报》
CSCD
1995年第3期273-275,共3页
Acta Pharmacologica Sinica
基金
Project supported in part by Joint Research Management Committee from a World Band Loan for Schistosomiasis. The Eight Five-year Key Research Program of China, №859170208.
