摘要
目的:比较16周自发性高血压大鼠(SHR)和对照组Wistar-Kyoto(WKY)大鼠中枢神经系统中与血压调节有关的核团内阿片受体密度的变化.方法:用放射自显影方法,运用氚标依托啡作配基检测阿片受体的分布. 结果:在海马(P<0.01)、中央灰质、孤束核、胸髓(P<0.05)几处,SHR阿片受体密度较WKY大鼠低;而在杏仁核(P<0.01)、僵核(P<0.05)和下丘脑核群包括弓状核(P<0.01),SHR却有较高的阿片受体密度. 结论:不同分布的阿片受体与自发性高血压大鼠的血压有关.
To compare the densities of opioid receptors in spontaneously hypertensive rats (SHR) with those of normotensive Wistar-Kyoto (WKY) rats in central nervous system which are related to the regulation of BP. METHODS : [3 H ] Etorphine , a nonspecific opioid ligand, was used to determine the distributions of opioid receptors in 16-wk-old SHR and WKY rats by quantitative autora-diography . RESULTS : The densities of [3H] etorphine in hippocampus (P<0. 01), periaqueductal gray, nucleus of the solitary tract, and thoracic (T4 - 6) spinal cord (P<0. 05) of SHR were lower than those of WKY rats. But in basolateral amygdaloid nucleus (P <C 0. 01), habenular nuclei (P < 0. 05 ) , and hypothalamic nuclei including arcuate nucleus (P<0.01), higher densities of opioid receptors were found in SHR. No difference existed in interpeduncular nuclei between the 2 groups. CONCLUSION: The difference in distributions of opioid receptors is related to the hypertension in SHR.
出处
《中国药理学报》
CSCD
1995年第4期341-344,共4页
Acta Pharmacologica Sinica
基金
Project supported by the National Natural Science Foundation of China, №39370235
by the Science Foundation from the Ministry of Public Health, №0758112.
关键词
依托啡
阿片受体
高血压
放射自显影
大鼠
etorphine
opioid receptors
hypertension
brain
spinal cord
autoradiography
inbred SHR rats
inbred WKY rats
