摘要
粉防己碱对家兔实验性心肌缺血及再灌注损伤的保护作用任佐军，曾定尹，章新华，焦克荣，王怀良（中国医科大学第一临床学院循环内科，沈阳基础医学院药理教研室，１１０００１）粉防己碱（ｔｅｔｒａｎｄｒｉｎｅ，Ｔｅｔ）具有Ｃａ２＋通道阻滞作用［１］，对整体心肌缺...
The effects of calcium antagoniststetrandrine(Tet)and nifedipine(Nif)on myocardialischemia and reperfusion injury were studied inurethane anesthetized rabbits subjected to 60 minocclusion of the left anterior descending coronary ar-tery followed by 20 min reperfusion. Tet 5 mg·kg -1 and Nif 80 μg·kg-1 were administered ivrespectively 20 min after ischemia. Both drugs show-ed a profound beneficial effects on the metabolicchanges including significant decrease of themalondialdehyde, lactate dehydrogenase, glutamic-oxalacetic transaminase and creatine kinase levels.without change of glutathione and glutationeperoxidase caused by myocardial ischemia andreperfusion seen in normal saline group. These re-sults indicated that pretreatment with Tet and Nifcould attenuate the myocardial ischemia andreperfusion injury.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1995年第4期303-304,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
粉防己碱
心肌缺血
再灌注损伤
保护
tetrandrine, nifedipine
ischemia
myocardial reperfusion injury
freeradicals
lipid peroxidation
