摘要
含杂环的β－锗代α－氨基酸倍半化合物的合成及抗肿瘤活性测定姜凤超，刘敏，赵智（武汉同济医科大学药学院，武汉４３００３０）某些含有吲哚３－取代及呋喃２－取代基的衍生物具有抑制谷胱甘肽－Ｓ－转移酶（ＧＳＴｓ）的活性，从而可逆转肿瘤耐药性而使某些具有细胞毒...
Some germanyl heterocyclic(indol-or furanal-)aminoacid derivatives,such as 1-(3′-indol)-2-amino-2-carboxyethylgermanium sesquioxide(ⅢA1),which may act as the GSTs inhibitor were designed and synthesizd.Pharmacological experimental results of these compounds showed that the p.o.LD50 for mice was more than 10 g/kg,when given p.o.,the inhibition of the growth ofS-180 ofⅢA1 and ⅢA2were comparable to that of 5-Fu(i.m.)under the same experimental condition.
出处
《中国药物化学杂志》
CAS
CSCD
1995年第3期202-204,共3页
Chinese Journal of Medicinal Chemistry
关键词
锗代氨基酸
倍半化合物
合成
抗癌药
药理学
Germanyl aminoacid derivatives
Heterocyclic compounds
Antitumor activity
