摘要
大果木姜子挥发油（ＣＶ－３）对离体内脏平滑肌和心血管平滑肌有松驰作用。采用结扎猫冠状动脉左前降支致急性实验性心肌缺血，以观察其抗心肌缺血作用。ＣＶ－３０．２ｍｌ／ｋｇ十二指肠给药后，心外膜电图ＳＴ段偏移总和∑－ＳＴ及偏移总导联数（Ｎ－ＳＴ）较生理盐水（ＮＳ）ｔａ显著减少。氯化硝基四氨唑蓝（Ｎ－ＢＴ）染色显示心肌梗塞范围较Ｎ８组缩小（Ｐ＜０．０１），并能降低梗塞后血清乳酸脱氢酶水平，表明ＣＶ－３对猫急性心肌缺血具有保护作用。
Acute myocardial ischemia was produced experimentally by high level ligation ofthe anterior descending branch of the left coronary artery(LAD)in anesthetised open-chest cats.The oil of Cinnamonzum migao(CV3)0.2 ml/kg was given. Nine point of epicardial electrocar-diogram showed that the sum of S-T segment elevation(∑-ST) and the number of S-T elevatingleads(N-ST)were decreased more remarkably than in NS group.Infarct size as indicated by N-BTstaining was reduced as compared with NS,P<0.05.The serum lacfate dehydrogenase(LDH)ac-tivity was lowered.These results indicated that CV-3 had protective effect on myocardialischemia.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第6期341-341,共1页
Chinese Pharmaceutical Journal
关键词
大果木姜子油
心肌缺血
心外膜电图
实验药理
Cinnamonzum migao oil,acute myocardial ischemia,epicardial electrocadiogram
