摘要
本文调查了６１名高氟区和４８名非高氟区７～１８岁青少年的骨龄，并测定了骨龄正常组和延迟组血清２５－羟维生素Ｄ（２５－ＯＨＤ）及血清钙、磷水平。结果发现，高氟区青少年骨龄延迟率显著高于非高氟区；高氟区骨龄延迟组的血清２５－ＯＨＤ水平显著低于该地骨龄正常组；高氟区２５－ＯＨＤ的水平低于非高氟区。提示，高氟区青少年骨龄延迟与血清２５－ＯＨＤ水平低有关。
e conducted a cross-sectional study of serum
25-hydroxymitamin D(25-OH D) level in 61 adoles-cents aged 7 18
yr,in an area of endemic fluorosis at a village in
Inner-mongolia,while 48 adolescentsin a normal area nearby were also
investigated.All adolescents were divided into two groups:skeletalage
retardation group and normal skeletal group.The concentrations of
serum fluoride, calcium andphosphorus were measured.The results
showed that the levels of serum 25-OH D in the former groupwere
significantly lower than that in the later in both areas(P<0.05).The
levels of serum 25-OH Dand calcium in adolescents living in
high-fluoride area showed markedly lower than that in normal
area(P<0. 05,P<0.01).In normal skeletal age group,the serum calcium
level in high fluoride area( P<0. 01).There was no statistic
difference in serum calcium level between skeletal retardation groups
inthese two areas. No difference was found in serum phosphorus levels
between these two areas andgroups. No correlation was observed
between levels of serum fluoride ,calcium and 25-OH D in both ar-eas.
These results suggested that bone growth and development was delayed
and the lower level ofserum 25-OH D might be related to the skeletal
age retardation in adolescents living high-fluoride area.It is still
unclear how high fluoeied intake influences the metabolism of vitamin
D in adolescents.
出处
《中国医科大学学报》
CAS
CSCD
1995年第1期33-35,共3页
Journal of China Medical University
基金
国家自然科学基金
