摘要
目的探讨腺苷蛋氨酸是否对肝部分切除术后残余肝脏功能具有保护作用。方法选择我科2010年1月~2010年5月间因肝细胞癌行肝部分切除术的患者,术后随机分为治疗组(SAMe)和空白对照组。SAMe组患者术后连续5天静脉给予SAMe1000mg,其余术后治疗两组一致,观察患者术后肝功能的恢复情况。结果本组共有59例,SAMe组29例,对照组30例。两组在年龄、性别、术前肝脏储备功能、合并肝硬化比例、切肝量、术中出血量以及肝门阻断时间等方面均无统计学差异。10例患者术后出现肝功能不全,对照组明显高于SAMe组(8/30vs2/29;P=0.040)。以肝门阻断时间大于15min做分层分析后发现,SAME组患者术后第5和第7天的总胆红素水平及术后胆红素峰值均明显低于对照组(P=0.049;P=0.030;P=0.040)。结论腺苷蛋氨酸能减少肝切除术后高胆红素血症的发生,对残留肝脏功能具有保护。当术中肝门阻断时间大于15分钟时,其保护作用更加明显。
Background To investigate the protective effects of S-adenosyl-L-methionine (SAMe) therapy on post-hepatectomy residual liver function. Patients and methods We studied 59 patients underwent resection of hepatocellular carcinoma. 29 paients were randomly assigned to receive postoperative intracenous SAMe treatment, and 30 were randomly assigned to a control group. The postoperative SAMe therapy consisted of SAMe 1000mg given intravenously for 5 days. The other postoperative treatment was standardized. Result...
出处
《肝胆外科杂志》
2011年第1期20-23,共4页
Journal of Hepatobiliary Surgery
关键词
肝切除
腺苷蛋氨酸
肝功能
肝门阻断
hepatectomy
S-adenosyl-L-methionine
liver function
hilar blocking
